:root{--bg:#f4f7fb;--panel:#fff;--panel-2:#edf2fa;--text:#0f172a;--muted:#475569;--accent:#1d4ed8;--accent-2:#0f766e;--danger:#b91c1c;--border:#cbd5e1;--button-fg:#fff;--error-bg:#fee2e2;--error-text:#7f1d1d;--mane-select-bg:#dbeafe;--mane-plus-bg:#ccfbf1;--consequence-bg:#ccfbf1;--sig-path-bg:#fee2e2;--sig-path-fg:#991b1b;--sig-path-border:#dc2626;--sig-lpath-bg:#ffedd5;--sig-lpath-fg:#9a3412;--sig-lpath-border:#ea580c;--sig-vus-bg:#fef3c7;--sig-vus-fg:#92400e;--sig-vus-border:#d97706;--sig-lbenign-bg:#ccfbf1;--sig-lbenign-fg:#115e59;--sig-lbenign-border:#0d9488;--sig-benign-bg:#99f6e4;--sig-benign-fg:#0f766e;--sig-benign-border:#0d9488}@media (prefers-color-scheme:dark){:root{--bg:#0b1020;--panel:#121a33;--panel-2:#0f1630;--text:#e7ecf5;--muted:#a8b3ca;--accent:#93b4ff;--accent-2:#68e7d0;--danger:#ff7d7d;--border:#2a3a68;--button-fg:#081024;--error-bg:hsla(0,100%,71%,.15);--error-text:#ffd9d9;--mane-select-bg:rgba(124,156,255,.2);--mane-plus-bg:rgba(91,224,200,.16);--consequence-bg:rgba(91,224,200,.16);--sig-path-bg:hsla(0,100%,71%,.2);--sig-path-fg:#ffc2c2;--sig-path-border:#ff7d7d;--sig-lpath-bg:rgba(255,170,107,.2);--sig-lpath-fg:#ffe0c2;--sig-lpath-border:#ffb172;--sig-vus-bg:rgba(255,220,107,.17);--sig-vus-fg:#ffeabf;--sig-vus-border:#ffd56d;--sig-lbenign-bg:rgba(91,224,200,.14);--sig-lbenign-fg:#c8f4ea;--sig-lbenign-border:#68e7d0;--sig-benign-bg:rgba(91,224,200,.2);--sig-benign-fg:#68e7d0;--sig-benign-border:#68e7d0}}*{box-sizing:border-box}body,html{margin:0;padding:0;background:var(--bg);color:var(--text);font-family:-apple-system,BlinkMacSystemFont,Segoe 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button:disabled{opacity:.6;cursor:not-allowed}a:focus-visible,button:focus-visible,code:focus-visible,input:focus-visible,select:focus-visible{outline:2px solid var(--accent);outline-offset:2px}.examples{color:var(--muted);font-size:13px;margin-bottom:24px}.examples code{background:var(--panel-2);padding:2px 6px;border-radius:4px;cursor:pointer}.examples code:hover{color:var(--accent)}.panel{background:var(--panel);border:1px solid var(--border);border-radius:10px;padding:16px 20px;margin-bottom:16px}.panel h2{font-size:15px;margin:0 0 12px;color:var(--muted);text-transform:uppercase;letter-spacing:.05em}.how-it-works{margin-bottom:20px}.how-it-works ol{margin:0;padding-left:18px;color:var(--text)}.how-it-works li+li{margin-top:6px}.group-block{padding:12px 0;border-bottom:1px dashed var(--border)}.group-block:last-child{border-bottom:0}.group-header{margin-bottom:8px}.group-title{font-weight:600;font-size:14px;font-family:ui-monospace,SFMono-Regular,Menlo,monospace;color:var(--text)}.group-sub{display:flex;flex-wrap:wrap;gap:8px;align-items:center;margin-top:4px;font-size:12px}.mane-badge{display:inline-block;margin-left:8px;padding:2px 8px;border-radius:10px;font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;vertical-align:middle}.mane-badge.mane-select{background:var(--mane-select-bg);color:var(--accent);border:1px solid var(--accent)}.mane-badge.mane-plus{background:var(--mane-plus-bg);color:var(--accent-2);border:1px solid var(--accent-2)}.mane-badge.canonical{background:transparent;color:var(--muted);border:1px solid var(--muted)}.consequence-pill{background:var(--consequence-bg);color:var(--accent-2);padding:2px 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0}.article:last-child{border-bottom:0}.article .title{font-weight:600;margin-bottom:4px}.article .meta{color:var(--muted);font-size:13px;margin-bottom:4px}.article .matched{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:12px;color:var(--accent-2)}.pubmed-nav{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:14px}.pubmed-nav-link{background:var(--panel-2);border:1px solid var(--border);border-radius:999px;padding:2px 10px;font-size:12px}.pubmed-section{margin-bottom:12px}.pubmed-section-title{margin:10px 0 0;color:var(--muted);font-size:13px;font-weight:600;font-family:ui-monospace,SFMono-Regular,Menlo,monospace}.spinner{color:var(--muted);font-style:italic}.clinvar-row{border-bottom:1px solid var(--border);padding:12px 0}.clinvar-row:last-child{border-bottom:0}.clinvar-row .title{font-weight:600;margin-bottom:4px;font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:13px}.clinvar-row .meta{color:var(--muted);font-size:12px;margin-bottom:4px}.clinvar-row .matched{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:12px;color:var(--accent-2)}.sig-badge{display:inline-block;margin-left:8px;padding:2px 8px;border-radius:10px;font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em}.sig-badge.sig-path{background:var(--sig-path-bg);color:var(--sig-path-fg);border:1px solid var(--sig-path-border)}.sig-badge.sig-lpath{background:var(--sig-lpath-bg);color:var(--sig-lpath-fg);border:1px solid var(--sig-lpath-border)}.sig-badge.sig-vus{background:var(--sig-vus-bg);color:var(--sig-vus-fg);border:1px solid var(--sig-vus-border)}.sig-badge.sig-lbenign{background:var(--sig-lbenign-bg);color:var(--sig-lbenign-fg);border:1px solid var(--sig-lbenign-border)}.sig-badge.sig-benign{background:var(--sig-benign-bg);color:var(--sig-benign-fg);border:1px solid var(--sig-benign-border)}.sig-badge.sig-other{background:transparent;color:var(--muted);border:1px solid var(--muted)}